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Bacteria Mediated Cancer Therapy

This project aims to address the problem of regrowth of tumor tissue after bacteriolytic treatment. Our goal is to develop a novel selectively aerotolerant strain of Clostridium that cannot colonize inside healthy tissue, but that could grow in the viable rim of an infected tumor. We hypothesize that aerotolerance is conferred by expression of an aerotolerance enzyme by an engineered strain of Clostridium sporogenes. To couple the selective expression of this gene to tumor colonization, it will be placed under the control of a promoter activated by a synthetic quorum sensing circuit.