Dive Into
Innovation!
-
Boosting Preclinical Drug Discovery Success with Zebrafish Larvae
-
Speeding Up Progress, and Cutting Costs
Need More Info
Let Us know What You Need!
Why Zebrafish Larvae?
- Greater similarity to humans as compared to cell culture systems
- Sharing 84% of the disease-associated genes with humans.
- Their transparent bodies allow for direct examination of the internal organs and their functions
- Cost-effective with results yielded in 6 days or less.
- Small enough to fit into a single well of a multi-well plate (6- to 384-wells), making it possible to perform high-throughput screening with small amounts of test compounds.
Our Services
CREM Co Labs conducts drug screening using zebrafish for a wide range of applications, including:
- Acute Toxicity: Assessment of drugs, cosmetics, and water toxicity at 2- and 4-days post fertilization (dpf) following OECD-236 guideline.
- Teratotoxicity: Assessment of drugs, cosmetics, and water at 2 and 4 dpf following modified OECD-236 guideline
- Cardiotoxicity: Heart rate measurement at 2 and 4 dpf using specific transgenics
- Neurotoxicity: Locomotion activity assay using DanioVision Noldus tracking system.
- Multi-toxicity: Combining cardio-, neuro- and terato-toxicity assays to select candidates with lower toxicity to reduce cost and time of high-throughput screening projects
- Epilepsy: Using a stablished method in 5 dpf larvae to identify compounds effective against epilepsy
- Amyotrophic Lateral Sclerosis (ALS): Using a novel method in 6 dpf larvae to identify potential drugs to cure ALS
- Diabetes: Glucose measurement in 7 dpf larvae to identify compounds efficient in lowering blood glucose levels.
- Brain Micro-bleeding (BMB)/Intracerebral Hemorrhage (ICH): Using established methods to identify efficient compounds to rescue the bleeding in 3 dpf larvae
- Parkinson: Using MPP+ model to identify potential drugs in 5 dpf larvae
- Anxiety: Thigmotaxis assay to identify anxiolytics and anxiogenics in 3 dpf larvae
- Stress: Assessment of locomotor activity and photomotor response in 5 dpf larvae by performing alternating light/dark locomotion assay using DanioVision Noldus tracking system to identify efficient compounds
- Wound Healing: Tailfin transection in 4 dpf larvae and assaying its healing 4 and 6 days after wounding to identify efficient compounds
- Anti-oxidation: In-vivo anti-oxidation assays in 3 dpf larvae to identify antioxidants for pharma and cosmetics
- Melanin Quantification: Using stablished methods in 2 dpf larvae to identify whitening-agents for cosmetics
- Rare Genetic Diseases: Generating knockdown zebrafish by using gene specific morpholino (antisense oligonucleotide) at 1 to 4 cell stage embryos and characterizing the induced phenotype to identify the compounds which show rescue effect and explore novel therapeutic strategies.
Standards & Regulations
Several standards and guidelines are already available for investigators on the ethical use of zebrafish, their proper husbandry, standardized dosing and exposure protocols, systematic data collection and analysis, implementation of quality control measures, and transparent reporting.
More Questions
Contact Us Now!
What about
Our Service Flow?
- Having a free consultation session upon contact to assess your needs for testing
- Provide a proposal/quote for the project
- Signing the contract/proposal
- Starting the project after receiving signed contract/ proposal and requested fund
- Updating the sponsor and discussing the challenges throughout the project
- Providing a detailed report for the experimental work
What are
Our Advantages?
- Under OECD Gool Laboratory Practice (GLP)
- Extensive experience and expertise in zebrafish drug screening
- Compliance with all relevant regulations and guidelines for zebrafish drug screening and international organizations (e.g., ISO, ASTM)
- Equipped with state-of-the-art laboratory facilities
Fast & Efficient
We look forward to seeing you!
We are here to help you
Save
Money & Time
At CREMCo Labs, we save your money and time by putting your technology under our pre-assessment testing. Our Pre-assessment program will clarify if your technology qualifies for registration or not, if yes we assure you get the best out of your technology when you are registered with EPA, FDA or Health Canada.
ABOUT US WE ARE THE
TRUSTED EXPERTS
Our EXPERT TEAM
We develop safer and more sustainable technologies as well as test protocols for environmental decontamination. We have devised several methods for testing disinfectants and hand hygiene agents.
We collaborate with universities and other research organizations to develop and refine cutting-edge technologies for the rapid and accurate detection of human pathogens in clinical and environmental samples.
CREM Co Labs has custom-built facilities as well as extensive experience for studying the fate of all major classes of human pathogens indoors and to assess technologies claiming air decontamination.
WHAT SPEAK PEOPLE
We've worked with CREMCO on many projects including regulatory submissions, product development & verification, etc. The team, especially Dr. Zargar and Dr. Sattar, provide input that is practical and insightful. Communication is always transparent, and delays are generally due to forces outside the lab. When delays occurred CREMCO worked with us to mitigate the impact on the overall timeline.
In response to the need for improved indoor air quality amidst the COVID-19 pandemic, our ZenGUARD™ antimicrobial coated HVAC filter was awarded a Candian Government contract which aimed to demonstrate a substantial reduction in airborne pathogens without compromising airflow rates. Partnering with CREMCO, experts in bioaerosol testing, was instrumental in developing and executing this novel testing protocol. We highly recommend working with CREMCO Laboratories.
I'm pleased to offer this testimonial for CREMCO Lab. Their expertise in antimicrobial testing, microbicide efficacy assessment, and air decontamination technology evaluation is exceptional. Their precision & scientific rigor have enhanced our product understanding, shaping our research through their meticulous real-world simulations and testing programs.