Acute Toxicity:
Assessing drugs, cosmetics, and water toxicity at 2 and 4 days post fertilization (dpf) following OECD-236 guideline with the following endpoints:
- Lack of heartbeat
- Lack of somites
- Coagulated embryos
- Non-detachment of the tail
Teratotoxicity:
Assessing drugs, cosmetics, and water at 2 and 4 dpf following modified OECD-236 guideline with the following morphological endpoints:
- Deformed body shape
- Yolk deformation
- Edema
- Hatching
- Necrosis
- Heart malformation
- Craniofacial malformation
Cardiotoxicity:
Heart rate measurement at 2 and 4 dpf using specific transgenics
Neurotoxicity:
Locomotion activity assay using DanioVision Noldus tracking system
Multi-toxicity:
Combining cardio-, neuro- and terato-toxicity assays to select candidates with lower toxicity to reduce cost
