Article Posts – Primer on Pathogens

Article Posts – Primer on Pathogens

Single-Celled Parasite Toxoplasma Gondii
An international team of neurobiologists has developed a way to use a single-celled parasite Toxoplasma Gondii to deliver therapeutic proteins directly into brain cells. In this study published in Nature Microbiology, the researchers addressed the challenge of the brain’s selective permeability, which restricts treatment options for neurological conditions.
characterization of the heterogeneity of cyclospora
A recent study funded by AMD and conducted by the CDC’s Division of Parasitic Diseases and Malaria revealed that Cyclospora cayetanensis is actually comprised of at least three distinct yet closely related single-celled organisms. Cyclosporiasis, a serious intestinal illness caused by the parasite Cyclospora cayetanensis, is linked to contaminated fresh fruits like raspberries.
Mpox virus, also known as the Monkeypox virus, is an enveloped double-stranded DNA virus classified within the Orthopoxvirus genus of the Poxviridae family. Monkeypox infection causes a milder illness compared to smallpox, consisting of an influenza-like prodrome followed by a distinctive vesiculopustular rash. Although Mpox primarily spread through close human contact, it can also be transmitted from contaminated surfaces and via indoor air.
A recent collaborative effort between NIZO Food Research and Wageningen University and Research (WUR) has shed light on the presence of microbial contaminants within 88 diverse plant-based ingredients used in dairy alternatives. The study identified a significant variation in the level of contamination, with a worrying prevalence of spore-forming microbes in many samples.
Avian Influenza A (H5N1) Virus
The circulation of the highly pathogenic avian influenzavirus (HPAI) H5N1 has intensified globally since 2021 with mass mortality in wild birds and poultry and incidental infections in mammals such as cattle.
The virus is a subtype of the influenza A virus belonging to the family Orthomyxoviridae which consists of viruses with a negative single-stranded RNA genome. The genome has eight segments encoding at least 11 different proteins, including hemagglutinin (HA) and neuraminidase (NA) glycoproteins.
Measles virus, a human pathogen, is in the genus Morbillivirus. It is an enveloped, single-stranded, non-segmented, negative-sense RNA virus. Its virions are pleomorphic (roughly spherical) in shape with a diameter of 300–500 nm. Parainfluenza and mumps viruses are within the genus Paramyxovirus, and the respiratory syncytial virus (RSV) and metapneumovirus are within the genus Pneumovirus.
Canada's ban prohibiting cosmetics animal testing and trade is enacted into law and has been into effect since December 22. This legislation which was enacted as part of the Budget Implementation Act (Bill C-47) in June 2023, bans cosmetic animal testing and the sale of products relying on new animal testing data to establish safety. It also prevents misleading labeling regarding animal testing for cosmetics.
Papillomaviruses are double-stranded DNA viruses with a particle diameter of about 55 nanometers (nm). They can infect the skin as well as the epithelium in all vertebrates including humans. Warts are a common form of HPV infection. Certain types of HPV can also cause carcinomas including those of the male (penis) and female (cervix) genitalia.
Researchers from the National University of Singapore have recently found a revolutionary method to grow human norovirus (HuNoV) in zebrafish embryos (1). HuNoV, a common and worldwide cause of acute non-bacterial gastroenteritis, has been refractory to culture in vitro as well as in vivo. The use of zebrafish embryos for HuNoV culture promises to an important breakthrough.
Human Adenovirus
Adenoviruses (from Latin adenos meaning 'gland') are icosahedral (about 90 nm in diam.), nonenveloped, double-stranded DNA viruses with a wide host range (mammals, birds, reptiles, amphibians, and fish). Characteristic antennae-like fibers protrude from the virion surface give them the appearance of miniature satellites. Virus replication occurs inside the nucleus of infected cells.