Stress is a natural physiological and psychological response to external pressures, but chronic stress can lead to severe health issues such as cardiovascular disease, depression, and anxiety. Symptoms include irritability, insomnia, and muscle tension. In North America, nearly 75% of adults report experiencing stress regularly. The market for stress-related treatments, including medication and therapy, is valued at $3.5 billion. There are no specific drugs for chronic stress, but therapies like antidepressants and anti-anxiety medications are often used. Companies developing drugs that specifically target chronic stress have significant potential due to the high prevalence and the growing awareness of stress-related health risks.Zebrafish Model: Assessment of locomotor activity and photomotor response in 5 dpf larvae by performing alternating light/dark locomotion assay using DanioVision Noldus tracking system to identify efficient compounds